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1

Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin

Račková, Lucia, Jančinová, Viera, Petríková, Margita, Drábiková, Katarína, Nosáľ, Radomír, Štefek, Milan, Košťálová, Daniela, Prónayová, Naďa, Kováčová, Mária

Journal:

Natural Product Research

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

2

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

Aldini, Giancarlo, Vistoli, Giulio, Stefek, Milan, Chondrogianni, N., Grune, Tilman, Sereikaite, Jolanta, Sadowska-Bartosz, Izabela, Bartosz, Grzegorz

Journal:

Free Radical Research

Year:

2013

Language:

english

File:

PDF, 3.15 MB

english, 2013

3

Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects

Lucia Račková, Magdaléna Májeková, Daniela Košt’álová, Milan Štefek

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 396 KB

english, 2004

4

Eye Lens in Aging and Diabetes: Effect of Quercetin

Stefek, Milan, Karasu, Cimen

Journal:

Rejuvenation Research

Year:

2011

Language:

english

File:

PDF, 229 KB

english, 2011

5

Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats

Prnova, Marta Soltesova, Kovacikova, Lucia, Svik, Karol, Bezek, Stefan, Elmazoğlu, Zübeyir, Karasu, Cimen, Stefek, Milan

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2019

File:

PDF, 541 KB

2019

6

Oxidation of liposomal membrane suppressed by flavonoids: Quantitative structure–activity relationship

Lucia Rackova, Silvia Firakova, Daniela Kostalova, Milan Stefek, Ernest Sturdik, Magdalena Majekova

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 309 KB

english, 2005

7

Effect of cadmium on hepatic microsomal monooxygenase activities in guinea pigs with low and high ascorbic acid intake

Anna Nagyova, Emil Ginter, Milan Štefek

Journal:

The Journal of Nutritional Biochemistry

Year:

1994

Language:

english

File:

PDF, 508 KB

english, 1994

8

Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors

Polyxeni Alexiou, Ioannis Nicolaou, Milan Stefek, Albin Kristl, Vassilis J. Demopoulos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 192 KB

english, 2008

9

Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

Milan Stefek, Vladimir Snirc, Paul-Omer Djoubissie, Magdalena Majekova, Vassilis Demopoulos, Lucia Rackova, Zelmira Bezakova, Cimen Karasu, Vincenzo Carbone, Ossama El-Kabbani

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

10

Structure–activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

Maria Chatzopoulou, Eduard Mamadou, Maria Juskova, Cathrine Koukoulitsa, Ioannis Nicolaou, Milan Stefek, Vassilis J. Demopoulos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 666 KB

english, 2011

11

Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells

E. Ümit Bağrıaçık, Kadriye Uslu, Erkan Yurtçu, Milan Stefek, Çimen Karasu

Journal:

Cell Biology International

Year:

2007

Language:

english

File:

PDF, 548 KB

english, 2007

12

Electrophoretic analysis of oxidatively modified eye lens proteins in vitro: implications for diabetic cataract

Zuzana Kysel’ová, L’udmila Križanová, Ladislav Šoltés, Milan Štefek

Journal:

Journal of Chromatography A

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

13

Erratum to “Electrophoretic analysis of oxidatively modified eye lens proteins in vitro: implications for diabetic cataract” [J. Chromatogr. A 1084 (2005) 95–100]

Zuzana Kyselová, Ľudmila Križanová, Ladislav Šoltés, Milan Štefek

Journal:

Journal of Chromatography A

Year:

2005

File:

PDF, 47 KB

2005

14

Gas chromatographic determination of stobadine, N-desmethylstobadine and stobadine N-oxide in rat liver microsomal incubations

Milan Štefek, Luděk Beneš

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1987

Language:

english

File:

PDF, 464 KB

english, 1987

15

Gas chromatographic determination of pentacaine in rat serum

Vladimír Marko, Milan Štefek, Ladislav Šoltés

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1985

Language:

english

File:

PDF, 220 KB

english, 1985

16

Efficient and selective isolation of local anaesthetics from biological fluids using C18 silica gel

Ladislav Šoltés, Dušan Berek, Milan Štefek

Journal:

Journal of Chromatography A

Year:

1984

Language:

english

File:

PDF, 298 KB

english, 1984

17

STOBADINE PROTECTS RAT KIDNEY AGAINST ISCHAEMIA/REPERFUSION INJURY

Galip Guz, Billur Demirogullari, Nuray N Ulusu, Cihangir Dogu, Arzu Demirtola, Mustafa Kavutcu, Suna Omeroglu, Milan Stefek, Cimen Karasu

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

18

Pentose Phosphate Pathway, Glutathione-Dependent Enzymes and Antioxidant Defense During Oxidative Stress in Diabetic Rodent Brain and Peripheral Organs: Effects of Stobadine and Vitamin E

Nuray N. Ulusu, Meral Sahilli, Aslihan Avci, Orhan Canbolat, Gülgün Ozansoy, Nuray Ari, Musa Bali, Milan Stefek, Svorad Stolc, Andrej Gajdosik, Çimen Karasu

Journal:

Neurochemical Research

Year:

2003

Language:

english

File:

PDF, 66 KB

english, 2003

19

Effects of Stobadine and Vitamin E in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress

Fatma Yülek, Meral Or, Candan Özoğul, Asli Ceylan Isik, Nuray Ari, Milan Stefek, Victor Bauer, Cimen Karasu

Journal:

Archives of Medical Research

Year:

2007

Language:

english

File:

PDF, 670 KB

english, 2007

20

(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: An aldose reductase inhibitor and antioxidant of zwitterionic nature

Milan Stefek, Anna Tsantili-Kakoulidou, Ivana Milackova, Maria Juskova, Vladimir Snirc, Nikos Triantos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 287 KB

english, 2011

21

Inhibition of Cumene Hydroperoxide-Induced Lipid Peroxidation by a Novel Pyridoindole Antioxidant in Rat Liver Microsomes

Milan Stefek, Maria Masarykova, Ludek Benes

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1992

Language:

english

File:

PDF, 446 KB

english, 1992

22

Inhibition of Alloxan-Induced Hyperglycaemia in Mice by the Pyridoindole Stobadine

Milan Stefek, Zuzana Trnkova

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1995

Language:

english

File:

PDF, 281 KB

english, 1995

23

The Pyridoindole Antioxidant Stobadine Prevents Alloxan-Induced Lipid Peroxidation by Inhibiting its Propagation

Milan Stefek, Zuzana Trnkova

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1996

Language:

english

File:

PDF, 482 KB

english, 1996

24

Substituted hexahydropyridoindoles—Effective scavengers of free radicals

Milan Stefek, Gregorz Bartosz, Maria Juskova, Ivana Milackova, Mojmir Mach

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 90 KB

english, 2012

25

In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+-ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E

Bilgehan Pekiner, Nuray N Ulusu, Net Das-Evcimen, Meral Sahilli, Fugen Aktan, Milan Stefek, Svorad Stolc, Çimen Karasu

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2002

Language:

english

File:

PDF, 196 KB

english, 2002

26

The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of streptozotocin-induced diabetic rats

Milan Stefek, Narcis Tribulova, Andrej Gajdosik, Alena Gajdosikova

Journal:

Acta Histochemica

Year:

2002

Language:

english

File:

PDF, 646 KB

english, 2002

27

Novel quercetin derivatives: synthesis and screening for anti-oxidant activity and aldose reductase inhibition

Veverka, Miroslav, Gallovič, Ján, Švajdlenka, Emil, Veverková, Eva, Prónayová, Naďa, Miláčková, Ivana, Štefek, Milan

Journal:

Chemical Papers

Year:

2013

Language:

english

File:

PDF, 211 KB

english, 2013

28

Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells

Račková, Lucia, Šnirc, Vladimír, Jung, Tobias, Štefek, Milan, Karasu, Çimen, Grune, Tilman

Journal:

Free Radical Research

Year:

2009

Language:

english

File:

PDF, 192 KB

english, 2009

29

Free Radical Scavenging and Antioxidant Activities of Substituted Hexahydropyridoindoles. Quantitative Structure−Activity Relationships

Rackova, Lucia, Snirc, Vladimir, Majekova, Magdalena, Majek, Pavol, Stefek, Milan

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 147 KB

english, 2006

30

Effect of Stobadine on Leukocyte Free Radical Generation in Streptozotocin-Diabetic Rats: Comparison with Vitamin E

Demiry&uuml, rek, A. Tuncay, Karasu, &Ccedil, imen, Stefek, Milan, Stolc, Svorad

Journal:

Year:

2004

Language:

english

File:

PDF, 68 KB

english, 2004

31

Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation

Chatzopoulou, Maria, Patsilinakos, Alexandros, Vallianatou, Theodosia, Prnova, Marta Soltesova, Žakelj, Simon, Ragno, Rino, Stefek, Milan, Kristl, Albin, Tsantili-Kakoulidou, Anna, Demopoulos, Vassili

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.97 MB

english, 2014

32

2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent

Milackova, Ivana, Prnova, Marta Soltesova, Majekova, Magdalena, Sotnikova, Ruzena, Stasko, Michal, Kovacikova, Lucia, Banerjee, Sreeparna, Veverka, Miroslav, Stefek, Milan

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 291 KB

english, 2015

33

Screening for antiradical efficiency of 21 semi-synthetic derivatives of quercetin in a DPPH assay

Milackova, Ivana, Kovacikova, Lucia, Veverka, Miroslav, Gallovic, Ján, Stefek, Milan

Journal:

Interdisciplinary Toxicology

Year:

2013

Language:

english

File:

PDF, 166 KB

english, 2013

34

New Route of BenzyneCyclization for Synthesis of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole Derivatives Avoiding Highly Toxic Aryl Hydrazines

Kovacikova, Lucia, Stefek, Milan

Journal:

Journal of Heterocyclic Chemistry

Year:

2014

Language:

english

File:

PDF, 459 KB

english, 2014

35

Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

Journal:

Interdisciplinary Toxicology

Year:

2011

Language:

english

File:

PDF, 241 KB

english, 2011

36

Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold

Stefek, Milan, Soltesova Prnova, Marta, Majekova, Magdalena, Rechlin, Chris, Heine, Andreas, Klebe, Gerhard

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.21 MB

english, 2015

37

Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts

Karasu, Çimen, Cumaoğlu, Ahmet, Gúrpinar, Ali, Kartal, Murat, Kovacikova, Lucia, Milackova, Ivana, Stefek, Milan

Journal:

Interdisciplinary Toxicology

Year:

2012

Language:

english

File:

PDF, 187 KB

english, 2012

38

Antioxidant action of SMe1EC2, the low-basicity derivative of the pyridoindole stobadine, in cell free chemical models and at cellular level

Balcerczyk, Aneta, Bartosz, Grzegorz, Drzewinska, Joanna, Piotrowski, Łukasz, Pulaski, Łukasz, Stefek, Milan

Journal:

Interdisciplinary Toxicology

Year:

2014

Language:

english

File:

PDF, 180 KB

english, 2014

39

Antioxidant action of the hexahydropyridoindole SMe1EC2 in the cellular system of isolated red blood cells in vitro

Stefek, Milan, Milackova, Ivana, Juskova-Karasova, Maria, Snirc, Vladimir

Journal:

Year:

2013

Language:

english

File:

PDF, 181 KB

english, 2013

40

Antioxidant action of 3-mercapto-5 H -1,2,4-triazino[5,6- b ]indole-5-acetic acid, an efficient aldose reductase inhibitor, in a 1,1′-diphenyl-2-picrylhydrazyl assay and in the cellular system of isolated erythrocytes exposed to tert -butyl hydroperoxide

Prnova, Marta Soltesova, Ballekova, Jana, Majekova, Magdalena, Stefek, Milan

Journal:

Year:

2015

Language:

english

File:

PDF, 311 KB

english, 2015

41

CHNQ, a novel 2-Chloro-1,4-naphthoquinone Derivative of Quercetin, induces Oxidative Stress and Autophagy both in vitro and in vivo

Enayat, Shabnam, Şeyma Ceyhan, M., Taşkoparan, Betül, Stefek, Milan, Banerjee, Sreeparna

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 7.21 MB

english, 2016

42

IN VITRO STUDIES ON THE ACTIVITY OF JAPANESE KAMPO HERBAL MEDICINES ORENGEDOKU- TO (TJ-15) AND TOKI-SHAKUYAKU-SAN (TJ-23) AS SCAVENGERS OF FREE RADICALS

Stefek, Milan, Benes, Ludek

Journal:

Drug Metabolism and Drug Interactions

Year:

1994

Language:

english

File:

PDF, 1.06 MB

english, 1994

43

ChemInform Abstract: New Route of Benzyne Cyclization for Synthesis of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole Derivatives Avoiding Highly Toxic Aryl Hydrazines.

Kovacikova, Lucia, Stefek, Milan

Journal:

Year:

2015

File:

PDF, 17 KB

2015

44

3′-O-(3-Chloropivaloyl)quercetin, α-glucosidase inhibitor with multi-targeted therapeutic potential in relation to diabetic complications

Soltesova-Prnova, Marta, Milackova, Ivana, Stefek, Milan

Journal:

Chemical Papers

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

45

Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases

Zizkova, Petronela, Stefek, Milan, Rackova, Lucia, Prnova, Marta, Horakova, Lubica

Journal:

Chemico-Biological Interactions

Year:

2017

Language:

english

File:

PDF, 1.49 MB

english, 2017

46

Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation

Papastavrou, Nikolaos, Chatzopoulou, Maria, Ballekova, Jana, Cappiello, Mario, Moschini, Roberta, Balestri, Francesco, Patsilinakos, Alexandros, Ragno, Rino, Stefek, Milan, Nicolaou, Ioannis

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

47

Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer

Taskoparan, Betul, Seza, Esin Gulce, Demirkol, Secil, Tuncer, Sinem, Stefek, Milan, Gure, Ali Osmay, Banerjee, Sreeparna

Journal:

Cellular Oncology

Year:

2017

Language:

english

File:

PDF, 4.91 MB

english, 2017

48

Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity

Majekova, Magdalena, Ballekova, Jana, Prnova, Marta, Stefek, Milan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

49

Chalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study

Kucerova-Chlupacova, Marta, Dosedel, Martin, Kunes, Jiri, Soltesova-Prnova, Marta, Majekova, Magdalena, Stefek, Milan

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

50

Substituted derivatives of indole acetic acid as aldose reductase inhibitors with antioxidant activity: structure-activity relationship

Juskova, Maria, Majekova, Magdalena, Demopoulos, Vassilis, Stefek,  Milan

Journal:

General Physiology and Biophysics

Year:

2012

Language:

english

File:

PDF, 536 KB

english, 2012

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